Kynurenine丨CAS 2922-83-0

Kynurenine is an intermediate in the metabolism of tryptophan through the kynurenine pathway and plays a critical role in biochemistry, pharmacology, and medical research. It is widely studied as a biomarker for immune activation, inflammation, and neurological disorders, making it important in clinical diagnostics and disease monitoring. In neuroscience, kynurenine and its downstream metabolites are investigated for their influence on glutamatergic signaling, neurodegeneration, and psychiatric conditions such as depression and schizophrenia. In immunology, it is used to study immune tolerance mechanisms, particularly its role in modulating T-cell activity via the enzyme indoleamine 2,3-dioxygenase (IDO). Beyond basic research, kynurenine serves as a reference standard in analytical chemistry and mass spectrometry for quantifying tryptophan metabolism products.

The benefits of kynurenine lie in its significance as both a biological marker and a mechanistic probe. Its central role in tryptophan metabolism makes it a valuable tool for understanding complex biochemical pathways that connect metabolism, immune response, and nervous system regulation. As a measurable metabolite, it enables researchers and clinicians to track disease progression and treatment responses with high specificity. Its availability as a pure compound supports reproducible research and precise quantification in laboratory assays. Furthermore, the study of kynurenine and its derivatives opens avenues for therapeutic innovation, particularly in immune-related and neurodegenerative diseases.